Gene name:
Plxna4(Kiaa1550);
Protein name:
Plexin-A4;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with NRP1 and NRP2.
Function:
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MKAMPWNWTC | LLSHLLVVGM | GSSTLLPRQP | PQLSQKPSFV | TFRGEPAEGF |
100:
NHLVVDERTG | HIYLGAVNRI | YKLSSDLKVL | VTHQTGPDED | NPKCYPPRIV |
150:
QTCNEPLAST | NNVNKMLLID | YKENRLIACG | SLYQGICKLL | RLEDLFKLGE |
200:
PFHKKEHYLS | GVNESGSVFG | VIVSYSNFDD | KLFIATAVDG | KPEYFPTISS |
250:
RKLTKNSEAD | GMFAYVFHDE | FVASMIKIPS | DTFTVIPDFD | IYYVYGFSSG |
300:
NFVYFLTLQP | EMVSPPGSTT | KEQVYTSKLV | RLCKEDTAFN | SYVEVPIGCE |
350:
RNGVEYRLLQ | AAYLSKAGAV | LGRTLGVRPD | DDLLFTVFSK | GQKRKMKSLD |
400:
ESALCIFILK | QINDRIKDRL | QSCYRGEGTL | DLAWLKVKDI | PCSSALLTID |
450:
DNFCGLDMNA | PLGVSEMVRG | IPVFTEDRDR | MTSVIAYVYK | NHSLAFVGTK |
500:
SGKLKKIRVD | GPKGNALQYE | TVQVVDSGPV | LRDMAFSKDH | EQLYIMSERQ |
550:
LTRVPVESCG | QYRSCGECLG | SGDPHCGWCV | LHNTCTRKER | CERSREPRRF |
600:
ASEMKQCVRL | TVHPNNISVS | QYNVLLVLET | YNVPELSAGV | NCTFEDLSEM |
650:
DGLVIGNQIQ | CYSPAAKEVP | RIITENGDHH | VVQLQLKSKE | TGMTFASTSF |
700:
VFYNCSVHNS | CLSCVESPYR | CHWCKYRHVC | THDPNTCSFQ | EGRVKLPEDC |
750:
PQLLRVDKIL | VPVEVIKPIT | LKAKNLPQPQ | SGQRGYECIL | NIQGIEQRVP |
800:
ALRFNSSSVQ | CQNTSYSYEG | MEINNLPVEL | TVVWNGHFNI | DNPAQNKVYL |
850:
YKCGAMRESC | GLCLKADPDF | ECGWCQSPGQ | CTLRQHCPAH | ESRWLELSGA |
900:
NSKCTNPRIT | EIIPVTGPRE | GGTKVTIRGE | NLGLEFRDIA | SHVKVAGVEC |
950:
SPLVDGYIPA | EQIVCEMGEA | KPSQHAGFVE | ICVAVCRPEF | MARSSQLYYF |
1000:
MTLTLADLKP | NRGPMSGGTQ | VTITGTNLNA | GSNVVVMFGS | QPCLFHRRSP |
1050:
SYIICNTTSS | EEVLDMKVTV | QVDRARIRQD | LVFQYVEDPT | IVRIEPEWSI |
1100:
VSGNTPIAVW | GTHLDLIQNP | QIRAKHGGKE | HINICEVLNA | TEMTCQAPAL |
1150:
ALGPDHQSDL | TERPEEFGFI | LDNVQSLLIL | NKTNFTYYPN | PVFEAFSPSG |
1200:
ILELKPGTPI | ILKGKNLIPP | VAGGNVKLNY | TVLVGEKPCT | VTVSDVQLLC |
1250:
ESPNLIGRHK | VMARVGGMEY | SPGMVYIAPD | SPLSLPAIVS | IAVAGGLLII |
1300:
FIVAVLIAYK | RKSRESDLTL | KRLQMQMDNL | ESRVALECKE | AFAELQTDIH |
1350:
ELTSDLDGAG | IPFLDYRTYT | MRVLFPGIED | HPVLRDLEVP | GYRQERVEKG |
1400:
LKLFAQLINN | KVFLLSFIRT | LESQRSFSMR | DRGNVASLIM | TVLQSKLEYA |
1450:
TDVLKQLLAD | LIDKNLESKN | HPKLLLRRTE | SVAEKMLTNW | FTFLLYKFLK |
1500:
ECAGEPLFSL | FCAIKQQMEK | GPIDAITGEA | RYSLSEDKLI | RQQIEYKTLV |
1550:
LSCVSPDNVN | SPEVPVKILN | CDTITQVKEK | ILDAIFKNVP | CSHRPKAADM |
1600:
DLEWRQGSGA | RMILQDEDIT | TKIENDWKRL | NTVAHYQVPD | GSVVALVSKQ |
1650:
VTAYNAVNNS | TVSRTSASKY | ENMIRYTGSP | DSLRSRTPMI | TPDLESGVKL |
1700:
WHLVKNHEHG | DQKEGDRGSK | MVSEIYLTRL | LATKGTLQKF | VDDLFETIFS |
1750:
TAHRGSALPL | AIKYMFDFLD | EQADKHGIHD | PHVRHTWKSN | CLPLRFWVNM |
1800:
IKNPQFVFDI | HKNSITDACL | SVVAQTFMDS | CSTSEHRLGK | DSPSNKLLYA |
1850:
KDIPSYKNWV | ERYYSDIGKM | PAISDQDMNA | YLAEQSRMHM | NEFNTMSALS |
1893:
EIFSYVGKYS | EEILGPLDHD | DQCGKQKLAY | KLEQVITLMS | LDS

Vaild Sequence:
Related Databases
Uniprot: