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Index > Protein center > Plxna4(Gene name) > Mouse
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  • Plxna4 (Gene name),
  • Plexin-A4 (Protein name ),  PLXA4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Plxna4(Kiaa1550);
    Protein name:
    Plexin-A4;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with NRP1 and NRP2.
    Function:
    Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1893
    Sequence:
    50:
    MKAMPWNWTC | LLSHLLVVGM | GSSTLLPRQP | PQLSQKPSFV | TFRGEPAEGF | 
    100:
    NHLVVDERTG | HIYLGAVNRI | YKLSSDLKVL | VTHQTGPDED | NPKCYPPRIV | 
    150:
    QTCNEPLAST | NNVNKMLLID | YKENRLIACG | SLYQGICKLL | RLEDLFKLGE | 
    200:
    PFHKKEHYLS | GVNESGSVFG | VIVSYSNFDD | KLFIATAVDG | KPEYFPTISS | 
    250:
    RKLTKNSEAD | GMFAYVFHDE | FVASMIKIPS | DTFTVIPDFD | IYYVYGFSSG | 
    300:
    NFVYFLTLQP | EMVSPPGSTT | KEQVYTSKLV | RLCKEDTAFN | SYVEVPIGCE | 
    350:
    RNGVEYRLLQ | AAYLSKAGAV | LGRTLGVRPD | DDLLFTVFSK | GQKRKMKSLD | 
    400:
    ESALCIFILK | QINDRIKDRL | QSCYRGEGTL | DLAWLKVKDI | PCSSALLTID | 
    450:
    DNFCGLDMNA | PLGVSEMVRG | IPVFTEDRDR | MTSVIAYVYK | NHSLAFVGTK | 
    500:
    SGKLKKIRVD | GPKGNALQYE | TVQVVDSGPV | LRDMAFSKDH | EQLYIMSERQ | 
    550:
    LTRVPVESCG | QYRSCGECLG | SGDPHCGWCV | LHNTCTRKER | CERSREPRRF | 
    600:
    ASEMKQCVRL | TVHPNNISVS | QYNVLLVLET | YNVPELSAGV | NCTFEDLSEM | 
    650:
    DGLVIGNQIQ | CYSPAAKEVP | RIITENGDHH | VVQLQLKSKE | TGMTFASTSF | 
    700:
    VFYNCSVHNS | CLSCVESPYR | CHWCKYRHVC | THDPNTCSFQ | EGRVKLPEDC | 
    750:
    PQLLRVDKIL | VPVEVIKPIT | LKAKNLPQPQ | SGQRGYECIL | NIQGIEQRVP | 
    800:
    ALRFNSSSVQ | CQNTSYSYEG | MEINNLPVEL | TVVWNGHFNI | DNPAQNKVYL | 
    850:
    YKCGAMRESC | GLCLKADPDF | ECGWCQSPGQ | CTLRQHCPAH | ESRWLELSGA | 
    900:
    NSKCTNPRIT | EIIPVTGPRE | GGTKVTIRGE | NLGLEFRDIA | SHVKVAGVEC | 
    950:
    SPLVDGYIPA | EQIVCEMGEA | KPSQHAGFVE | ICVAVCRPEF | MARSSQLYYF | 
    1000:
    MTLTLADLKP | NRGPMSGGTQ | VTITGTNLNA | GSNVVVMFGS | QPCLFHRRSP | 
    1050:
    SYIICNTTSS | EEVLDMKVTV | QVDRARIRQD | LVFQYVEDPT | IVRIEPEWSI | 
    1100:
    VSGNTPIAVW | GTHLDLIQNP | QIRAKHGGKE | HINICEVLNA | TEMTCQAPAL | 
    1150:
    ALGPDHQSDL | TERPEEFGFI | LDNVQSLLIL | NKTNFTYYPN | PVFEAFSPSG | 
    1200:
    ILELKPGTPI | ILKGKNLIPP | VAGGNVKLNY | TVLVGEKPCT | VTVSDVQLLC | 
    1250:
    ESPNLIGRHK | VMARVGGMEY | SPGMVYIAPD | SPLSLPAIVS | IAVAGGLLII | 
    1300:
    FIVAVLIAYK | RKSRESDLTL | KRLQMQMDNL | ESRVALECKE | AFAELQTDIH | 
    1350:
    ELTSDLDGAG | IPFLDYRTYT | MRVLFPGIED | HPVLRDLEVP | GYRQERVEKG | 
    1400:
    LKLFAQLINN | KVFLLSFIRT | LESQRSFSMR | DRGNVASLIM | TVLQSKLEYA | 
    1450:
    TDVLKQLLAD | LIDKNLESKN | HPKLLLRRTE | SVAEKMLTNW | FTFLLYKFLK | 
    1500:
    ECAGEPLFSL | FCAIKQQMEK | GPIDAITGEA | RYSLSEDKLI | RQQIEYKTLV | 
    1550:
    LSCVSPDNVN | SPEVPVKILN | CDTITQVKEK | ILDAIFKNVP | CSHRPKAADM | 
    1600:
    DLEWRQGSGA | RMILQDEDIT | TKIENDWKRL | NTVAHYQVPD | GSVVALVSKQ | 
    1650:
    VTAYNAVNNS | TVSRTSASKY | ENMIRYTGSP | DSLRSRTPMI | TPDLESGVKL | 
    1700:
    WHLVKNHEHG | DQKEGDRGSK | MVSEIYLTRL | LATKGTLQKF | VDDLFETIFS | 
    1750:
    TAHRGSALPL | AIKYMFDFLD | EQADKHGIHD | PHVRHTWKSN | CLPLRFWVNM | 
    1800:
    IKNPQFVFDI | HKNSITDACL | SVVAQTFMDS | CSTSEHRLGK | DSPSNKLLYA | 
    1850:
    KDIPSYKNWV | ERYYSDIGKM | PAISDQDMNA | YLAEQSRMHM | NEFNTMSALS | 
    1893:
    EIFSYVGKYS | EEILGPLDHD | DQCGKQKLAY | KLEQVITLMS | LDS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Plexin-A4
    Cat.:
    E13272m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Plexin-A4
    Cat.:
    E13272h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Plexin-A4
    Cat.:
    U13272h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Plexin-A4
    Cat.:
    U13272m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Plexin-A4
    Cat.:
    P13272Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Plexin-A4
    Cat.:
    P13272Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Plexin-A4
    Monoclonal Antibody for Mouse Plexin-A4
    Protein for Mouse Plexin-A4
    Protein for Mouse Plexin-A4

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification and characterization of a novel mouse plexin, plexin-A4."
      Suto F. , Murakami Y. , Nakamura F. , Goshima Y. , Fujisawa H.
      Mech. Dev.120:385-396(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      tissue: Embryonic brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1042-1893
      strain: C57BL/6J.
      tissue: Spinal ganglion.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R.F. , Ohara R. , Inamoto S. , Nagase T. , Ohara O. , Koga H.
      Submitted (2005-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1695-1893
      tissue: Fetal brain.
    5. 5.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    6. 6.
      "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
      Schwarz Q. , Waimey K.E. , Golding M. , Takamatsu H. , Kumanogoh A. , Fujisawa H. , Cheng H.J. , Ruhrberg C.
      Dev. Biol.324:1-9(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    7. 7.
      "Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors."
      Waimey K.E. , Huang P.H. , Chen M. , Cheng H.J.
      Dev. Biol.315:448-458(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;INTERACTION WITH NRP1 AND NRP2;FUNCTION
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